Description

Clomid is the anti-estrogen of choice for enhancing the recovery of natural testosterone production after a cycle, improving the testosterone production of endurance athletes, and is also effective in reducing the risk of gynecomastia during a cycle using steroids. flavourable. Although it has been claimed that Clomid 'stimulates' the production of LH and thus testosterone, in fact Clomid's activity is not achieved by stimulating the hypothalamus and pituitary, but by blocking their inhibition by estrogen. Clomid is a mixed estrogen agonist/antagonist (activator/blocker) that, when bound to the estrogen receptor, puts it into a somewhat different conformation (shape) than estradiol. The estrogen receptor requires the binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without cofactor binding, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist – the cofactor used in that tissue cannot bind and so the receptor remains inactive – and in others Clomid acts as an agonist (activator), because the cofactors used in that tissue are able to unite. Clomid is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and to improve blood cholesterol. Clomid also has the property of reducing the adverse effect of exercise-induced damage of muscle tissue.This is very important for endurance athletes, but not very significant, if significant at all, with reasonable weight training. Clomid does not noticeably perceive weight trainer gains, either favorably or adversely in my experience. The drug appears to have estrogenic effects on mood, which may be beneficial (improving relationships with women by improving empathy) or may produce depression or PMS-like symptoms, but for most users there is no such effect. no significant effect. The statement that the duration of intake should not exceed 10 to 14 days is incorrect. Clinical studies with male patients have been for periods of one year or more. This error probably stems from the fact that, for use in women, due to the menstrual cycle it would obviously not make sense to try to stimulate ovulation during all four weeks of the month. Therefore, use in women is limited to 10-14 days. This limitation is not due to toxicity. In fact, Clomid is useful during a cycle if aromatizable drugs are used. I believe however that to be conservative, it should be used no more than 2/3 of the time throughout the year or a little less.